Efficient Niementowski synthesis of novel 1,3,10,12-tetra-substituted-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-ones
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Synthesis of tetra-substituted phenanthroimidazole derivatives using SBA-Pr-SO3H
A one pot four-component reaction of 9,10-phenanthraquinone, aromatic aldehyde, aniline, and ammonium acetate was designed for the preparation of tetrasubstituted imidazoles (phenanthro[9,10-d]imidazole) derivatives in the presence of SBA-Pr-SO3H as a mesoporous solid acid catalyst. Phenanthro[9,10-d]imidazole derivatives were produced by the use of this technique in short reaction times and go...
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5-Alkyl-6-(substituted benzyl)-2-thiouracils 3a,c were reacted with (2-chloroethyl) diethylamine hydrochloride to afford the corresponding 2-(2-diethylamino)ethylthiopyrimidin- 4(3H)-ones 4a,b. Reaction of 3a-c with N-(2-chloroethyl)pyrrolidine hydrochloride and/or N-(2-chloroethyl)piperidine hydrochloride gave the corresponding 2-[2-(pyrrolidin-1-yl)ethyl]-thiopyrimidin-4(3H)-ones 5a-c and 2-[...
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Heterocyclic compounds are very widely distributed in nature and are essential to life as they play a vital role in the metabolism of living cells. There are a vast number of pharmacologically active heterocyclic compounds of which many are in regular therapeutic usage. Among various heterocyclic compounds, quinoline-based drugs such as quinine, chloroquine, pamaquine and quinacrine are well kn...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2007
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0008.g01